These columns stand for Interest Rate Difference and Rate Spread Difference. They're calculated by subtracting the Control Mean for a specific section of the report (i.e. Joint Race, -Ethnicity, -Minority Status, -Gender, HMDA Applicant Income, Tract Income, Tract Minority) from a Target Mean for that same section.
For example, to get the Rate Spread Diff value for Joint Ethnicity - Hispanic/Latino, take the Rate Spread Mean value and subtract the corresponding mean value for Not Hispanic/Latino.